PBC in the News

Summary News

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• Rising awareness and media coverage of liver diseases, particularly PBC, including expert discussions and patient stories on various platforms.
• Promising clinical trial results for new PBC treatments such as linerixibat, seladelpar (Livdelzi), and elafibranor (Iqirvo), showing improvements in symptoms like itch and fatigue.
• Regulatory progress with multiple approvals and conditional authorizations of PBC treatments across Europe, the US, and the UK (e.g., Livdelzi, Iqirvo).
• Ongoing research into the mechanisms and associated conditions of PBC, including links to lymphoma, systemic sclerosis, and gut microbiota.
• Growing investment and milestone payments in the PBC drug development sector, reflecting commercial interest and expanding treatment options.
• Studies highlighting the importance of early diagnosis, personalized treatment plans, and quality of life improvements for PBC patients.
• Concerns over safety and effectiveness of existing treatments, with regulatory bodies declining or revoking approvals (e.g., Ocaliva).
• Educational efforts through art, patient stories, and physician guidance to support awareness and understanding of rare liver diseases like PBC.

News Articles

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26/10/2026 Peribiliary immune niche reframes primary biliary cholangitis - EurekAlert!

26/10/2026 Seronegative Autoimmune Hepatitis With Primary Biliary Cholangitis Features Presenting As Acute Biliary Disease: A Case Report - Cureus

23/10/2026 Gilead to Present New Data on Treatment Response and Long-Term Management of Rare Liver Diseases at The Liver Meeting® 2026 - BioSpace

22/10/2026 'Constipation Cookies'; Antibiotics and IBS; Primary Biliary Cholangitis Guidelines - MedPage Today

22/10/2026 AGA and AASLD issue recommendations on primary biliary cholangitis — News-Medical - UA.NEWS

22/10/2026 AGA/AASLD joint guideline evaluates newer medications for primary biliary cholangitis - News-Medical

22/10/2026 Gilead to Present New Data on Treatment Response and Long-Term Management of Rare Liver Diseases at The Liver Meeting® 2026 - Business Wire

21/10/2026 Korea approves Gilead's Livdelzi for primary biliary cholangitis - Korea Biomedical Review

19/10/2026 Elafibranor Bests Obeticholic Acid for ALP Normalization in PBC - HCPLive

16/10/2026 Looking Beyond the Numbers: Addressing the Full Burden of PBC - EMJ

15/10/2026 Response to Saroglitzar as Second-Line Treatment for Primary Biliary Cholangitis is Similar in US, Other Locations - Gastroenterology Advisor

14/10/2026 Plasma Proteomics Uncovers Biomarkers in Patients with PBC - EMJ

13/10/2026 Regional Differences in Saroglitazar Response in PBC, With Raj Vuppalanchi, MD - HCPLive

12/10/2026 Zydus Therapeutics Presents New Post Hoc Analysis of Phase 3 EPICS-III Trial at ACG 2026 Showing Greater Biochemical Response With Investigational Saroglitazar Compared to Placebo Across Geographic Subgroups in PBC - Yahoo Finance

01/10/2026 Sjögren’s Disease With Primary Biliary Cholangitis Fulfilling the 2010 ACR/EULAR Classification Criteria for Rheumatoid Arthritis: A Case Report and Review of an Under-Recognized Overlap - Cureus

28/09/2026 Primary Biliary Cholangitis Awareness Month - WGN-TV

28/09/2026 PBC Awareness Month Shines a Light on Support and Symptoms - WJLA

23/09/2026 The Citizen Newspaper Group - The Citizen Newspaper Group

19/09/2026 Antimitochondrial antibody measurements in the diagnosis of antimitochondrial antibody-negative and alkaline phosphatase-positive primary biliary cholangitis - EurekAlert!

18/09/2026 PBC Awareness, NFP Brings Community Together for International PBC Day - The Times Weekly

13/09/2026 Physician Views Preview: Livdelzi gets two-year reality check from PBC prescribers - FirstWord Pharma

10/09/2026 Gilead Helps Make the Unseen Symptoms of PBC Visible through Film and Poetry - Gilead Sciences

09/09/2026 Livdelzi accepted in Scotland for treatment of PBC - PharmaTimes

07/09/2026 Sleep disorders in primary biliary cholangitis: A prospective analysis of clinical and patient-reported outcomes - www.elsevier.com

04/09/2026 Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling - Nature

03/09/2026 Temporal trends in the epidemiology of primary biliary cholangitis in the public healthcare system of Brazil: a large population-based study - The Lancet

01/09/2026 Patients Suffering from Primary Biliary Cholangitis (PBC) Push Back on Stigma - Yahoo Finance

24/08/2026 PBC patients see disease markers rebound after trial as Korea reimbursement lags - Korea Biomedical Review

18/08/2026 Primary Biliary Cholangitis: A New Treatment Paradigm - Gastroenterology & Endoscopy News

30/07/2026 Lynavoy recommended for EU approval by the CHMP - PharmaTimes

29/07/2026 A dual time window-driven strategy to optimize primary biliary cholangitis treatment via alkaline phosphatase normalization - EurekAlert!

28/07/2026 Efficacy, symptoms, and safety of second-line PBC therapies: a network meta-analysis - Frontiers

28/07/2026 Primary Biliary Cholangitis in the Middle East: A Review of Current Challenges and Treatment Approaches - The Cureus Journal of Medical Science

28/07/2026 Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome With Limited Systemic Sclerosis - The Cureus Journal of Medical Science

28/07/2026 EMA Supports New Oral Treatment for PBC Itch - Medscape

24/07/2026 Linerixibat secures CHMP backing as first targeted therapy for cholestatic pruritus in primary biliary cholangitis. - AllSci

23/07/2026 Emerging PPAR therapies offer new hope for primary biliary cholangitis - News-Medical

23/07/2026 New approaches to treating a rare disease affecting the liver - UB - Universitat de Barcelona

22/07/2026 What To Eat To Help Manage Primary Biliary Cholangitis - Cleveland Clinic Health Essentials

17/07/2026 Primary Sclerosing Cholangitis in an Elderly Female With Concomitant Gallstone Disease: A Diagnostic Challenge and Literature Review - Cureus

13/07/2026 Improving Disease Management in Primary Biliary Cholangitis - EMJ

13/07/2026 Looking Beyond the Numbers: Addressing the Full Burden of PBC - EMJ

13/07/2026 ELSPIRE: Elafibranor Achieves Robust ALP Normalization in PBC - Medical Professionals Reference

13/07/2026 Elafibranor Achieves 85% ALP Normalization in Phase 3b ELSPIRE Trial for PBC - HCPLive

09/07/2026 Saroglitazar and the Evolving PBC Treatment Landscape, With Raj Vuppalanchi, MD - HCPLive

07/07/2026 Resistant primary biliary cholangitis: treatment with Elafibranor - Clínica FEHV

07/07/2026 Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis - Nature

06/07/2026 Liver–kidney crosstalk in primary biliary cholangitis: insights into the mechanisms of renal involvement - Frontiers

03/07/2026 Nearly 1 in 10 Patients With Primary Biliary Cholangitis Have Chronic Kidney Disease - Medscape

30/06/2026 Selective PPARα Modulator "K-808" (Pemafibrate) Granted "Breakthrough Therapy" Designation by the U.S. Food and Drug Administration (FDA) As a Treatment for Primary Biliary Cholangitis - Yahoo Finance

21/06/2026 Circulating matrix metalloproteinase profile in early-stage primary biliary cholangitis - Nature

17/06/2026 Scientists ID, test 2 immune proteins as possible therapeutic targets in PBC - Liver Disease News

10/06/2026 Saroglitazar Targets Bile Acid Dysregulation, Inflammation in PBC, With Raj Vuppalanchi, MD - HCPLive

09/06/2026 Seladelpar (Livdelzi) raises the bar for primary biliary cholangitis treatment - 2 Minute Medicine

08/06/2026 NICE approves seladelpar for primary biliary cholangitis - The Pharmaceutical Journal

05/06/2026 Seladelpar Given Go-Ahead by NICE for PBC Treatment - Medscape

03/06/2026 Gilead eyes PBC expansion for Livdelzi on positive one-year data - Clinical Trials Arena

02/06/2026 Gilead’s Livdelzi® (Seladelpar) Delivers Statistically Significant Composite ALP Normalization in Phase 3 IDEAL Trial in Primary Biliary Cholangitis (PBC) - Yahoo Finance

02/06/2026 Gilead's Livdelzi scores in rare liver disease trial, portending use in broader patient population - Fierce Pharma

01/06/2026 Saroglitazar Boosts Response Rates in Primary Biliary Cholangitis - MedPage Today

28/05/2026 FDA Grants Priority Review to Saroglitazar NDA for Primary Biliary Cholangitis - HCPLive

28/05/2026 Zydus Therapeutics New Drug Application (NDA) for Saroglitazar to Treat Primary Biliary Cholangitis (PBC) Granted Priority Review by the US FDA - Yahoo Finance

27/05/2026 Oral ABI-6250 may move into Phase 2 clinical testing for PBC and PSC - Liver Disease News

27/05/2026 Dear Doctor: Two rare, deadly diseases that have some similarities, but I can’t find info about one - Syracuse.com

21/05/2026 Overlap Syndrome Between Autoimmune Hepatitis and Primary Sclerosing Cholangitis in a Seven-Year-Old Child: A Case Report - The Cureus Journal of Medical Science

19/05/2026 Treatment Sequencing in Primary Biliary Cholangitis - Medscape Reference

18/05/2026 Mesenchymal stem cells in intrahepatic and extrahepatic biliary diseases: mechanisms and therapeutic applications - Frontiers

18/05/2026 Addressing the Symptom Burden of Primary Biliary Cholangitis - Medscape Reference: Drugs, Diseases & Medical Procedures

12/05/2026 Can Hypnosis Help Women With Primary Biliary Cholangitis and Fatigue? Read the Study in the May Issue of The American Journal of Gastroenterology | Newswise - Newswise

05/05/2026 Fenofibrate-UDCA Combination Therapy Safe and Effective for Primary Biliary Cholangitis - Cleveland Clinic

05/05/2026 UK Regulator Clears Treatment for PBC-Related Itch - Medscape

05/05/2026 Primary goal achieved in Mirum’s Phase IIb trial of volixibat - Clinical Trials Arena

04/05/2026 Editorial: UDCA Dosing in PBC – Between Guideline Adherence and Clinical Reality - Wiley Online Library

15/04/2026 Off-label fenofibrate improves liver health in PBC patients: Study - Liver Disease News

14/04/2026 Unraveling immunological heterogeneity in recalcitrant AIH-PBC/PSC overlap syndromes: from molecular crosstalk to precision therapeutics - Frontiers

10/04/2026 Early MRCP surveillance for recurrent primary sclerosing cholangitis after liver transplantation: a prospective imaging study - Nature

06/04/2026 Baseline Alkaline Phosphatase Impacts Response Rates in Primary Biliary Cholangitis: Exploring Response to Elafibranor in ELATIVE - Wiley Online Library

03/04/2026 Seladelpar Improved Itch, Itch-Related Sleep Disturbance and Measures of Fatigue in Patients With Primary Biliary Cholangitis and Pruritus in the Phase 3 RESPONSE Trial - Wiley Online Library

02/04/2026 Molecular mechanisms underlying T cell subset imbalance and precision therapeutic targets in primary biliary cholangitis - Frontiers

31/03/2026 The impact of male sex on outcomes in primary biliary cholangitis - Nature

20/03/2026 Protect Your Well-Being With Primary Biliary Cholangitis - Everyday Health

20/03/2026 FDA approves treatment for debilitating itch in rare liver disease - Managed Healthcare Executive

19/03/2026 FDA Approves Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis - The American Journal of Managed Care

19/03/2026 FDA approves first drug for itch due to primary biliary cholangitis - FirstWord Pharma

19/03/2026 FDA Approves Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis - Pharmacy Times

19/03/2026 FDA Approves Linerixibat (Lynavoy) As First Treatment for Cholestatic Pruritus in PBC - HCPLive

09/03/2026 Alfasigma bets up to $690M on GSK’s late-stage PBC itch drug ahead of FDA decision - European Biotechnology Magazine

04/03/2026 New PBC therapy found to reduce liver scarring after 1 year in US trial - Liver Disease News

03/03/2026 COUR Pharma reports one-year Phase IIa data for PLGA nanoparticle drug in primary biliary cholangitis - AllSci

02/03/2026 Impact of Alkaline Phosphatase Normalization on... : American Journal of Gastroenterology - Ovid

19/02/2026 Statin Use Linked to Lower Hepatic Decompensation Risk in Primary Biliary Cholangitis - Medscape

11/02/2026 Shifting the Clinical Conversation Around Statins in PBC, With Jonggi Choi, MD, PhD - HCPLive

11/02/2026 Primary biliary cholangitis–associated osteoporosis: contemporary review of pathogenesis and management - EurekAlert!

10/02/2026 Statins and Improved Long-Term Liver Outcomes in PBC, With Jonggi Choi, MD, PhD - HCPLive

26/01/2026 An Overview of PBC Pathophysiology, Severity, and Burden - HCPLive

22/01/2026 Closing Gaps in PBC Care With Emerging and Established Second-Line Treatments - HCPLive

14/01/2026 Diagnostic potential of salivary biomarkers for primary biliary cholangitis: a systematic review - Frontiers

23/12/2025 Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization | Scientific Reports - Nature

22/12/2025 Treating primary biliary cholangitis - Mayo Clinic Press

27/11/2025 Altered sphingolipid profile in primary biliary cholangitis: associations with fibrosis and inflammation - Nature