Summary News Back
Rising awareness and media coverage of liver diseases, particularly PBC, including expert discussions and patient stories on various platforms.
Promising clinical trial results for new PBC treatments such as linerixibat, seladelpar (Livdelzi), and elafibranor (Iqirvo), showing improvements in symptoms like itch and fatigue.
Regulatory progress with multiple approvals and conditional authorizations of PBC treatments across Europe, the US, and the UK (e.g., Livdelzi, Iqirvo).
Ongoing research into the mechanisms and associated conditions of PBC, including links to lymphoma, systemic sclerosis, and gut microbiota.
Growing investment and milestone payments in the PBC drug development sector, reflecting commercial interest and expanding treatment options.
Studies highlighting the importance of early diagnosis, personalized treatment plans, and quality of life improvements for PBC patients.
Concerns over safety and effectiveness of existing treatments, with regulatory bodies declining or revoking approvals (e.g., Ocaliva).
Educational efforts through art, patient stories, and physician guidance to support awareness and understanding of rare liver diseases like PBC.
News Articles Back
25/09/2025 Identification of Galangin as a Therapeutic Candidate for Primary Biliary Cholangitis via Systematic Druggable Genome-Wide Mendelian Randomization Analysis and Experimental Validation - Frontiers
18/09/2025 Liver Lineup: Innovations in Cholestatic Disease Management, With Kris Kowdley, MD - HCPLive
17/09/2025 The role of mitochondria-related key genes in primary biliary cholangitis was analyzed based on transcriptome sequencing data - Frontiers
13/09/2025 New Hope for People Living with PBC in Europe – ELPA - Oncodaily
10/09/2025 Gilead fashions new primary biliary cholangitis campaign alongside 'Project Runway' designer - Fierce Pharma
05/09/2025 Innate immunity of bile and cholangiocytes in Primary Biliary Cholangitis - Frontiers
25/08/2025 Understanding PBC: Managing what Matters Most - Ipsen
14/08/2025 Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci - Frontiers
09/08/2025 Early assessment of treatment response in primary biliary cholangitis: key to timely management - BMC Gastroenterology
06/08/2025 (PDF) Neuromuscular manifestations of primary biliary cholangitis: Two case reports and literature review - researchgate.net
03/08/2025 Research progress and perspectives of non-coding RNAs in primary biliary cholangitis: from mechanisms to therapeutics - Frontiers
24/07/2025 Exploration of Novel Metabolic Mechanisms Underlying Primary Biliary Cholangitis Using Hepatic Metabolomics, Lipidomics, and Proteomics Analysis - ACS Publications
23/07/2025 PPAR agonists effective in UDCA-resistant primary biliary cholangitis - Liver Disease News
18/07/2025 The effectiveness of combining ursodeoxycholic acid with vitamin D in treating patients with primary biliary cholangitis and its impact on hepatic fibrosis: a randomized trial - BMC Gastroenterology
17/07/2025 GSK’s Linerixibat Poised to Address Substantial Unmet Need for the Treatment of Pruritus Associated with Primary Biliary Cholangitis, According to Spherix Global Insights - GlobeNewswire
08/07/2025 The role of HLA-G in primary biliary cholangitis and response to therapy - Frontiers
02/07/2025 Endothelial cells expressing CPE and vWF are involved in the Immunopathogenesis of primary biliary cholangitis - Nature
30/06/2025 Treatment of pruritus in primary biliary cholangitis - Clínica FEHV
25/06/2025 EMA to review linerixibat for itch in primary biliary cholangitis - Liver Disease News
22/06/2025 Primary biliary cholangitis: A historical perspective from xanthomatous lesions to modern molecular biology - Baishideng Publishing Group
21/06/2025 biliary cirrhosis and primary sclerosing cholangitis - researchgate.net
20/06/2025 Novel Therapies for Primary Biliary Cholangitis - Medscape Reference
12/06/2025 Primary biliary cholangitis and the narrowing gap towards optimal disease control - The Lancet
04/06/2025 $2.27 Bn Primary Biliary Cholangitis Market Forecasts and - GlobeNewswire
19/05/2025 Global Epidemiology of Primary Biliary Cholangitis: An Updated Systematic Review and Meta-analysis - ScienceDirect.com
14/05/2025 Even with past treatment, Livdelzi works on primary biliary cholangitis - Liver Disease News
08/05/2025 Oral IBAT Inhibitor Improves Cholestatic Itch in Primary Biliary Cholangitis - MedPage Today
07/05/2025 Bringing PBC Into Focus Through Art of Patient Stories - Gilead Sciences
07/05/2025 Gilead’s Livdelzi® (Seladelpar) Demonstrated Consistent Efficacy and Safety Regardless of Prior Treatment History in New Data Presented at EASL 2025 - Yahoo Finance
29/04/2025 Gilead to Present Latest Advancements Across Primary Biliary Cholangitis and Viral Hepatitis - Business Wire
28/04/2025 Health Canada approves IQIRVO® as a first-in-class dual-peroxisome proliferator-activated receptor treatment for primary biliary cholangitis - Ipsen
23/04/2025 90% of People With This Rare Liver Disease Are Women—Meet the Patient Advocate Helping Empower Others - Flow Space
15/04/2025 Development of a Question Prompt List for People Living With Primary Biliary Cholangitis: A Delphi Study - ScienceDirect.com
14/04/2025 Bibliometric analysis of research on intestinal flora and primary biliary cholangitis published between 2004 and 2024 using VOSviewer and CiteSpace visualization - Frontiers
11/04/2025 Implementation of a care bundle improves PBC management - ScienceDirect.com
10/04/2025 Systemic Sclerosis and Primary Biliary Cholangitis: A Comprehensive Review of Two Overlapping Rare Entities With Insights on Diagnostics and Management - Cureus
08/04/2025 Ipsen’s Iqirvo accepted by SMC to treat rare liver disease primary biliary cholangitis - PMLiVE
07/04/2025 The Scottish Medicines Consortium (SMC) accepts Ipsen’s IQIRVO® (elafibranor) for use in NHS Scotland – the first new medicine in nearly a decade for primary biliary cholangitis (PBC), a rare liver disease - Ipsen
07/04/2025 New vision for rare liver condition - HealthandCare.scot
21/03/2025 The Evolving Primary Biliary Cholangitis Landscape, with Craig Lammert, MD - HCPLive
13/03/2025 Primary sclerosing cholangitis - Nature
07/03/2025 A Rare Case of Concurrent Primary Biliary Cholangitis and Sarcoidosis - Cureus
07/03/2025 Autoimmune Gastritis Complicated by Primary Biliary Cholangitis: A Report of Two Cases and Literature Review - Cureus
26/02/2025 Guidelines on the diagnosis and management of primary biliary cholangitis - EurekAlert!
24/02/2025 Breaking Grounds: A Comprehensive Analysis of Cutting-Edge Treatments for Primary Biliary Cirrhosis/Primary Biliary Cholangitis With Futuristic Treatments - Cureus
20/02/2025 Risk factors for mortality in patients with primary biliary cholangitis: a nomogram to predict 5-year survival - Frontiers
20/02/2025 Gilead’s Seladelpar Granted Conditional European Marketing Authorization for the Treatment of Primary Biliary Cholangitis - Yahoo Finance
05/02/2025 Poor primary biliary cholangitis outcomes linked with two self-reactive antibodies - Liver Disease News
20/01/2025 New treatment for primary biliary cholangitis - Clínica FEHV
20/01/2025 Gilead’s Livdelzi approved by MHRA to treat primary biliary cholangitis in adults - PMLiVE
15/01/2025 (PDF) The impact of deep response to ursodeoxycholic acid in primary biliary cholangitis - should it be the new clinical standard? - researchgate.net
13/01/2025 Seladelpar Approval PBC Treatment - Gastroenterology & Endoscopy News
10/01/2025 Gut microbiome pattern impacts treatment response in primary biliary cholangitis - ScienceDirect.com
10/01/2025 Gut microbiome pattern impacts treatment response in primary biliary cholangitis - ScienceDirect.com
10/01/2025 Exploration of Novel Metabolic Mechanisms Underlying Primary Biliary Cholangitis Using Hepatic Metabolomics, Lipidomics, and Proteomics Analysis - ACS Publications
10/01/2025 FDA Grants Orphan Drug Designation to CNP-104 for Primary Biliary Cholangitis - Pharmacy Times
08/01/2025 FDA Grants Orphan Drug Designation to CNP-104 for Primary Biliary Cholangitis - HCPLive
06/01/2025 A Rare Case of Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome in a Male Patient - Cureus
02/01/2025 Serious liver injury being observed in patients without cirrhosis taki - fda.gov
28/12/2024 Development and external validation of an early prediction model to identify irresponsive patients and prognosis of UDCA treatment in primary biliary cholangitis - Nature
25/12/2024 Second-Line Treatment for Patients With Primary Biliary Cholangitis: A Systematic Review With Network Meta-Analysis - Wiley Online Library
23/12/2024 Prompt Diagnosis, Management of Primary Biliary Cholangitis Key to Quality of Life - MedPage Today
13/12/2024 Noninvasive Assessment of portal Hypertension in Patients With Primary Biliary Cholangitis Is Affected by Severity of Cholestasis - ScienceDirect.com
13/12/2024 EMA Recommends Seladelpar for Primary Biliary Cholangitis - Medscape
13/12/2024 Gilead’s Seladelpar Receives Positive CHMP Opinion for Primary Biliary Cholangitis - BioSpace
30/11/2024 Expanded Treatment Options for Primary Biliary Cholangitis Leave Open Questions - MedPage Today
29/11/2024 Primary Biliary Cholangitis (PBC): Symptoms, Causes & Treatment Options - Metropolis Healthcare
26/11/2024 Answering Common Questions About Primary Biliary Cholangitis - Cleveland Clinic Health Essentials
19/11/2024 Diabetes Linked to Worse Transplant-Free Survival in Primary Biliary Cholangitis - HCPLive
16/11/2024 Bidirectional Mendelian randomization links gut microbiota to primary biliary cholangitis - Nature
15/11/2024 Primary Biliary Cholangitis Incidence and Prevalence Growing - MedPage Today
14/11/2024 VIDEO: ‘Encouraging’ safety data on Livdelzi in primary biliary cholangitis, cirrhosis - Healio
13/11/2024 Primary biliary cholangitis: What does successful treatment look like? - Mayo Clinic Press
13/11/2024 Primary biliary cholangitis: Your guide to diet and nutrition - Mayo Clinic Press
12/11/2024 FDA denies Ocaliva full approval in primary biliary cholangitis; safety data still in play - Healio
12/11/2024 Turning ambition into action: improving care for women with primary biliary cholangitis - Politics Home
07/11/2024 Gilead says launch of primary biliary cholangitis drug surpasses expectations - FirstWord Pharma
07/11/2024 Comparative diagnostic efficacy of two-dimensional shear wave and transient elastography in predicting the risk of esophagogastric varices and histological staging in patients with primary biliary cholangitis - BMC Gastroenterology
23/10/2024 Full approval on Ocaliva for primary biliary cholangitis delayed - Liver Disease News
17/10/2024 FDA Extends Review of Obeticholic Acid (Ocaliva) sNDA for Primary Biliary Cholangitis - HCPLive
14/10/2024 Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis - ScienceDirect.com
10/10/2024 Volixibat Granted Breakthrough Therapy Designation for Cholestatic Pruritus in Primary Biliary Cholangitis - Business Wire
07/10/2024 Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis - Nature
02/10/2024 Psychological factors and biochemical indicators influencing sleep disturbance of patients with primary biliary cholangitis in China: a cross-sectional survey analysis - Frontiers
06/09/2024 A home-based exercise programme attenuates fatigue in primary biliary cholangitis: Results from the EXCITED clinical trial - ScienceDirect.com
02/09/2024 Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis - ScienceDirect.com
18/07/2024 Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis - ScienceDirect.com
09/07/2024 Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis - ScienceDirect.com
26/06/2024 Roles of Non-Coding RNAs in Primary Biliary Cholangitis - Frontiers
06/06/2024 Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study - ScienceDirect.com
21/05/2024 Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization - Nature
21/02/2024 A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis - NEJM
11/02/2024 Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis? - Frontiers
10/02/2024 Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products - Frontiers
05/02/2024 New insights on the role of human leukocyte antigen complex in primary biliary cholangitis - Frontiers
22/11/2023 Animal models of primary biliary cholangitis: status and challenges - Cell & Bioscience
16/11/2023 Clinical trial results suggest potential new treatment for primary biliary cholangitis - University of California - Davis Health
01/12/2021 Primary Biliary Cholangitis - American Liver Foundation
25/05/2021 The pathogenesis, models and therapeutic advances of primary biliary cholangitis - ScienceDirect.com
09/12/2019 Primary biliary cholangitis: pathogenesis and therapeutic opportunities - Nature
