PBC in the News

Summary News

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• Rising awareness and media coverage of liver diseases, particularly PBC, including expert discussions and patient stories on various platforms.
• Promising clinical trial results for new PBC treatments such as linerixibat, seladelpar (Livdelzi), and elafibranor (Iqirvo), showing improvements in symptoms like itch and fatigue.
• Regulatory progress with multiple approvals and conditional authorizations of PBC treatments across Europe, the US, and the UK (e.g., Livdelzi, Iqirvo).
• Ongoing research into the mechanisms and associated conditions of PBC, including links to lymphoma, systemic sclerosis, and gut microbiota.
• Growing investment and milestone payments in the PBC drug development sector, reflecting commercial interest and expanding treatment options.
• Studies highlighting the importance of early diagnosis, personalized treatment plans, and quality of life improvements for PBC patients.
• Concerns over safety and effectiveness of existing treatments, with regulatory bodies declining or revoking approvals (e.g., Ocaliva).
• Educational efforts through art, patient stories, and physician guidance to support awareness and understanding of rare liver diseases like PBC.

News Articles

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12/02/2026 GENFIT to receive US$20M milestone after Ipsen’s Iqirvo® - GlobeNewswire

12/02/2026 Primary biliary cholangitis–associated osteoporosis: contemporary review of pathogenesis and management - EurekAlert!

11/02/2026 Shifting the Clinical Conversation Around Statins in PBC, With Jonggi Choi, MD, PhD - HCPLive

11/02/2026 Noninvasive combo tests for liver damage could replace biopsies in PBC - Liver Disease News

11/02/2026 Primary Biliary Cholangitis Market: Accelerating Growth and Pipeline Impact by 2034 - DelveInsight - openPR.com

11/02/2026 Osteoporosis in PBC: Pathogenesis and Management Review - Mirage News

10/02/2026 Statins and Improved Long-Term Liver Outcomes in PBC, With Jonggi Choi, MD, PhD - HCPLive

09/02/2026 How Special Populations and Disease Risk Impact Treatment Assessment in PBC - HCPLive

09/02/2026 Experts Review the First- and Second-Line Treatment Options for PBC - HCPLive

09/02/2026 NCPE Rejects Full HTA for Gilead’s Lyvdelzi in Treating Primary Biliary Cholangitis - NAVLIN DAILY

05/02/2026 Primary Sclerosing Cholangitis Market Outlook Highlights Rising Demand and Expanding Treatment Landscape Throughout the Forecast Period (2025-2034) | DelveInsight - Yahoo Finance

05/02/2026  - Medscape

28/01/2026 Primary Biliary Cholangitis Therapeutics Market to Reach $1.36 Billion | Update by AMR - openPR.com

02/01/2026 Seladelpar reduced pruritus in PBC as early as ‘first month, and persisted’ - Healio

23/12/2025 Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization | Scientific Reports - Nature

22/12/2025 Treating primary biliary cholangitis - Mayo Clinic Press

17/12/2025 Compound found in honey reduced inflammation in PBC mice in lab - Liver Disease News

17/12/2025 RIPK1 inhibition reduces biliary injury and fibrosis in primary sclerosing cholangitis - Science | AAAS

10/12/2025 Major Developments in the PBC Pruritus Treatment Pipeline - Gastroenterology & Endoscopy News

09/12/2025 Dysgeusia-Driven Nutritional Decline in Cirrhosis: A Case of Autoimmune Hepatitis and Primary Biliary Cholangitis - Cureus

03/12/2025 Read "Enhancing NIH Research on Autoimmune Disease" at NAP.edu - National Academies of Sciences, Engineering, and Medicine

03/12/2025 Shifts in Blood Lipids Linked to Early Primary Biliary Cholangitis - European Medical Journal

27/11/2025 Altered sphingolipid profile in primary biliary cholangitis: associations with fibrosis and inflammation - Nature

27/11/2025 Pruritus Exhausts Primary Sclerosing Cholangitis Patients - Medscape

26/11/2025 Transjugular intrahepatic portosystemic shunt for hepatic sinusoidal obstruction syndrome with primary biliary cholangitis and alcoholic liver disease: a case report - Frontiers

21/11/2025 Patients with Primary Biliary Cholangitis Miss Recommended Monitoring - European Medical Journal

20/11/2025 VIDEO: Iqirvo may stabilize primary biliary cholangitis progression after long-term use - Healio

19/11/2025 Blood group A linked to a higher risk of primary biliary cholangitis - News-Medical

19/11/2025 PBC Awareness Day: Confronting Bias and Elevating Patient Voices - Ipsen

18/11/2025 Primary Biliary Cholangitis (PBC) Treatment Market to Reach USD 2.72 Billion by 2033, Driven by Next-Generation FXR Agonists & Immunomodulators | DataM Intelligence - PR Newswire

12/11/2025 Livdelzi maintains benefits for up to 3 years in PBC: Phase 3 data - Liver Disease News

10/11/2025 Seladelpar Staves Off Liver Stiffness in PBC - Medscape

10/11/2025 Seladelpar’s Impact on Liver Stiffness Measurements in PBC, With Christopher Bowlus, MD - HCPLive

10/11/2025 Gilead’s Livdelzi® Demonstrates Sustained Efficacy in Primary Biliary Cholangitis (PBC), Offering Alkaline Phosphatase (ALP) Reduction, Itch Relief and Potential to Slow Disease Progression - BioSpace

09/11/2025 Elafibranor Benefits Fatigue-Related Pathways Linked to Mitochondrial Function in PBC - HCPLive

08/11/2025 Seladelpar’s Long-Term Benefit for Pruritus in PBC, With Gideon Hirschfield, FRCP, PhD - HCPLive

07/11/2025 Volixibat Improves Fatigue and Sleep in Patients With Primary Biliary Cholangitis - HCPLive

07/11/2025 Ipsen to present two late-breaking sessions at AASLD on new PBC data supporting IQIRVO®’s long-term efficacy, safety and mechanistic insights in fatigue - Yahoo Finance

30/10/2025 Seladelpar’s Impact on Pruritus in Primary Biliary Cholangitis, With Marlyn Mayo, MD - HCPLive

30/10/2025 Elafibranor More Cost-Effective Than Seladelpar for Second-Line PBC Treatment - HCPLive

30/10/2025 Ipsen at The Liver Meeting 2025 - Ipsen

29/10/2025 Research Communication: Real-World Clinical Experience With Seladelpar in Primary Biliary Cholangitis - Wiley Online Library

27/10/2025 Exploring primary biliary cholangitis - Healio

26/10/2025 Advancing the management of primary biliary cholangitis: From pathogenesis to emerging therapies - Baishideng Publishing Group

23/10/2025 (Seladelpar) in Primary Biliary Cholangitis (PBC) and Investigational Bulevirtide in Chronic Hepatitis Delta - Business Wire

14/10/2025 Multi-omics tests identify novel shared genetic mechanisms of primary biliary cholestasis and sarcopenia - Nature

10/10/2025 Bezafibrate for primary biliary cholangitis: time to act on the evidence - Nature

09/10/2025 Beyond Ursodeoxycholic Acid: A Comprehensive Review of Second-Line Agents in Primary Biliary Cholangitis - Cureus

07/10/2025 Linerixibat Reduces Itching in PBC - Medscape

01/10/2025 PBC worst for life quality among autoimmune liver diseases: Study - Liver Disease News

17/09/2025 PBC treatment Ocaliva leaves U.S. market amid safety concerns - Liver Disease News

15/09/2025 Common pathological mechanisms and therapeutic strategies in primary Sjogren’s syndrome and primary biliary cholangitis: from tissue immune microenvironment to targeted therapy - Frontiers

12/09/2025 Liver Disease Drug Pulled From the Market - MedPage Today

11/09/2025 Ocaliva for Primary Biliary Cholangitis Withdrawn From US Market - Medscape

11/09/2025 Intercept Announces Voluntary Withdrawal of OCALIVA® for Primary Biliary Cholangitis (PBC) from the US Market; US Clinical Trials Involving Obeticholic Acid Placed on Clinical Hold - Yahoo Finance

10/09/2025 Gilead fashions new primary biliary cholangitis campaign alongside 'Project Runway' designer - Fierce Pharma

10/09/2025 September's PBC Awareness Month raises support for a rare liver... - Liver Disease News

08/09/2025 Progress in PBC, PSC: Key Updates in Cholestatic Liver Disease Care With Ann Moore, NP - HCPLive

05/09/2025 Innate immunity of bile and cholangiocytes in primary biliary cholangitis - Frontiers

01/09/2025 Zydus to file for PBC drug approval, but fierce competition looms - Clinical Trials Arena

29/08/2025 Zydus Therapeutics Reports Positive Topline Results from EPICS-III Phase 2(b)/3 Trial of Saroglitazar Magnesium in Patients with Primary Biliary Cholangitis - PR Newswire

29/08/2025 Zydus tees up US application after saroglitazar's late-stage success in PBC - FirstWord Pharma

27/08/2025 Blood marker LMR can predict liver function improvement in PBC - Liver Disease News

27/08/2025 Local Woman Launches Support Group For People With Primary Biliary Cholangitis - The Citizen Newspaper Group

26/08/2025 An experimental study on the effect of symptom expectations on mental fatigue and motivation in people with primary biliary cholangitis - Nature

25/08/2025 Understanding PBC: Managing what Matters Most - Ipsen

07/08/2025 Dendritic Cell-Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis - Wiley Online Library

06/08/2025 Adding Vitamin D boosts PBC treatment in clinical trial - Liver Disease News

03/08/2025 Research progress and perspectives of non-coding RNAs in primary biliary cholangitis: from mechanisms to therapeutics - Frontiers

23/07/2025 PPAR agonists effective in UDCA-resistant primary biliary cholangitis - Liver Disease News

17/07/2025 GSK’s Linerixibat Poised to Address Substantial Unmet Need for the Treatment of Pruritus Associated with Primary Biliary Cholangitis, According to Spherix Global Insights - Yahoo Finance

08/07/2025 Fulminant Primary Biliary Cholangitis-Autoimmune Hepatitis (PBC-AIH) Overlap Syndrome in a 27-Year-Old Woman With Childhood-Onset AIH: Steroid-Refractory Decompensation Necessitating Urgent Transplant Evaluation - Cureus

02/07/2025 Endothelial cells expressing CPE and vWF are involved in the Immunopathogenesis of primary biliary cholangitis - Nature

02/07/2025 Nearly half of PBC patients in US haven’t seen a specialist recently - Liver Disease News

30/06/2025 Treatment of pruritus in primary biliary cholangitis - Clínica FEHV

27/06/2025 Gilead Art Campaign Captures The PBC Patient Experience, Inspires Patient-Centric Trials - Clinical Leader

25/06/2025 EMA to review linerixibat for primary biliary cholangitis-related itch - Liver Disease News

23/06/2025 EU kicks off review of GSK's linerixibat in PBC - pharmaphorum

20/06/2025 Novel Therapies for Primary Biliary Cholangitis - Medscape

12/06/2025 Primary biliary cholangitis and the narrowing gap towards optimal disease control - The Lancet

11/06/2025 Trial of golexanolone for PBC cognitive symptoms to resume - Liver Disease News

04/06/2025 FDA Accepts GSKs NDA for First-in-Class IBAT Inhibitor Linerixibat to Treat Cholestatic Pruritus in Primary Biliary Cholangitis - Pharmaceutical Executive

22/05/2025 New Kids on the Block: Peroxisome Proliferator-Activated Receptor Agonists in Primary Biliary Cholangitis - European Medical Journal

19/05/2025 Double Trouble: Drug-Induced Autoimmune Hepatitis (AIH)-Primary Biliary Cholangitis (PBC) Overlap Syndrome Triggered by Hydralazine - Cureus

15/05/2025 Seladelpar Safe Effective Primary Biliary Cholangitis Cirrhosis PBC - Gastroenterology & Endoscopy News

15/05/2025 Betrayed by bile ducts? Researchers look for clues to treating a mysterious autoimmune disease - Medical Xpress

14/05/2025 Livdelzi effective on primary biliary cholangitis, regardless of prior treatment - Liver Disease News

09/05/2025 Gilead’s Livdelzi Shows Lasting Efficacy in Primary Biliary Cholangitis, Regardless of Prior Therapy - Pharmaceutical Executive

08/05/2025 Iqirvo Shows Significant Fatigue Improvement in Patients with Primary Biliary Cholangitis After 52 Weeks in Phase III ELATIVE Trial - Applied Clinical Trials Online

07/05/2025 Bringing PBC Into Focus Through Art of Patient Stories - Gilead Sciences

29/04/2025 Biochemical and Plasma Lipid Responses to Pemafibrate in Patients With Primary Biliary Cholangitis and Dyslipidemia: A Four-Year Analysis - Cureus

28/04/2025 Health Canada approves IQIRVO® as a first-in-class dual-peroxisome proliferator-activated receptor treatment for primary biliary cholangitis - Ipsen

23/04/2025 90% of People With This Rare Liver Disease Are Women—Meet the Patient Advocate Helping Empower Others - Flow Space

14/04/2025 Bibliometric analysis of research on intestinal flora and primary biliary cholangitis published between 2004 and 2024 using VOSviewer and CiteSpace visualization - Frontiers

10/04/2025 Systemic Sclerosis and Primary Biliary Cholangitis: A Comprehensive Review of Two Overlapping Rare Entities With Insights on Diagnostics and Management - Cureus

09/04/2025 Scotland's NHS to cover Iqirvo for eligible adults with primary biliary cholangitis - Liver Disease News

08/04/2025 Ipsen’s Iqirvo accepted by SMC to treat rare liver disease primary biliary cholangitis - PMLiVE

21/03/2025 The Evolving Primary Biliary Cholangitis Landscape, with Craig Lammert, MD - HCPLive

07/03/2025 A Rare Case of Concurrent Primary Biliary Cholangitis and Sarcoidosis - Cureus

24/02/2025 Breaking Grounds: A Comprehensive Analysis of Cutting-Edge Treatments for Primary Biliary Cirrhosis/Primary Biliary Cholangitis With Futuristic Treatments - Cureus